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    The pharmacokinetics and bioavailability of these drugs will be discussed below.

    The effects of amphetamine use on 5-HT metabolism and 5-HT reuptake from the circulation are summarized in .

    Effects on Serotonin Rebound

    For many years, the effects of amphetamine on metabolism and reuptake of 5-HT have been poorly studied as a result of methodological deficiencies in the studies reviewed before. Unfortunately, the main problem has been that many of the studies examined were conducted with patients with a severe and disabling mental disorder. As a consequence, most authors failed to consider that a significant reduction in 5-HT reuptake (the “uptake/rebound ratio”) occurs during withdrawal from amphetamines by patients with psychiatric disorders.

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