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Treatments with testosterone alone led to improvements in phallic dimensions and other histologic features, but failed to restore these features to controlled levels. In contrast, combination treatments completely normalised all penile dimensions. Histological assessments showed corresponding benefits of combined hormone treatments, and although collagen I overexpression was not prevented, all treated microphallic rats had significantly decreased testicular volumes, and further losses of testicular volumes due to testosterone monotherapy were ameliorated. The salient observation of this study was that cotreatments with GH augment the tropic effects of testosterone, serovital hgh and breast cancer. We confirmed that testosterone monotherapy significantly, albeit partially, restores penile dimensions in hypogonadal rats, as shown previously (12, 13).
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