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    The men were randomised to Weight Watchers weight loss programme plus placebo versus the same weight loss programme plus testosteroneand placebo.

    Participants were randomly assigned in groups to follow their intended diet. The men were randomly assigned in groups to Weight Watchers diet and testosterone or placebo.

    The average weight of the participants and diet were both compared. The study was carried out on 9 men of average body weight who were randomly assigned as follows:

    1st condition: Weight Watchers diet, 4% weight reduction; testosterone, 0.3 mg/day; placebo, 1 mg/day

    2nd condition: Weight Watchers diet, 4% weight reduction; testosterone only (1.0 mg/day); placebo, 0.3 mg/day and placebo, 1 mg/day

    3rd condition: Weight Watchers diet, 4% reduction; testosterone only (0.5 mg/day), placebo, 0.3 mg/day and placebo, 0.4 mg/day

    Results:

    Participants in the four conditions had lower body weight, BMI, fat-free weight, body mass index and waist-to-hip ratio.

    Weight-loss effects were dose-dependent. At the low end of the range, weight loss of 0.3% of average body weight resulted in a 6.5% gain in waist circumference, a 7.6% gain in lean tissue and increased fat free mass (measured by total body composition), resulting in a 4.8% change in percentage body fat.

    The difference between low-dose and high-dose testosterone was not significant for percent body fat. However, for body mass index and fat-free mass, differences across conditions were significant. In the lower doses, reductions in percentage body fat were less and no difference was seen in body mass index. The higher dose of testosterone resulted in more changes in both body mass index and fat-free mass.

    The most important differences were in abdominal fat, bone mineral density and liver fat.

    Comment:

    This study was carried out to further our understanding of how weight loss with testosterone may occur.

    High doses of testosterone may be beneficial for weight loss due mainly to reductions in visceral fat, visceral fat deposits and increases in blood flow to the body to allow these substances to be distributed into cells.

    This means that there are some potential positive effects in reducing inflammation.

    In this study, we do observe weight loss with low doses of testosterone. This will help us develop a more effective weight loss treatment.

    References:

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