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For instance, aromatase inhibitors have been developed to prevent or reverse adverse effects caused by testosterone on the body. These medications consist of a group of compounds including clomiphene (Vioxx®; Pfizer), desogestrel (Depo-Provera®, Eli Lilly-Pittsburgh); norethindrone benzoate (Depakene®; Novartis, LLC, in the United States); and flutamide (Ameritas Pharma, Inc. Aromatase inhibitors such as clomiphene and desogestrel have been shown to reduce testosterone production in the testes in rats, . However, studies have shown that aromatase inhibitors can also stimulate testosterone levels to higher than levels that would occur naturally during puberty. These stimulatory doses of testosterone were not as effective as levels that the rat’s body naturally produced.
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