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17 Although there is little direct evidence that topical steroid therapy affects the risk of developing cardiovascular disease, the following two articles may be helpful in explaining how topical steroids can increase the risk of developing cardiovascular disease over a lifetime: The association between topical steroids and cardiovascular events: A systematic review of randomized controlled trials of topical steroid use The association between steroid use and risk of all-cause and cardiovascular disease mortality in the elderly: A meta-analysis of randomized controlled trials of oral and topical steroids A small meta-analysis published in the American Journal of Cardiology found that topical steroids induce lipid peroxidation which may be responsible for the increased incidence of cardiovascular events, winstrol fat burner reviews.
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